FLUORES | Certus



PHARMACODYNAMICS: Fluconazole is antifungal medication of triazole group. It is a powerful selective inhibitor of sterol synthesis in fungal cells.Fluconazole selectively inhibits P-450 system of the fungus.

PHARMACOKINETICS: The medication is wholly and quickly absorbed after it has been taken. Bioavailability after oral administration is more than 90%; in 1-2 hours it creates the maximum concentration in the blood. After 400 mg of medicine is taken in it generates the peak concentration in plasma as 6.72 g / ml. The excretion half-time is 30 hours. Unlike other medications of azoles’ group it is less bound with proteins and penetrates quite well into the cerebrospinal fluid, into the joint fluid, in the saliva, in the bronchial secretion, in vaginal fluid and peritoneal fluid. More than 80% is output in unchanged form through the kidneys, and for this reason, during the dysfunction of kidney the excretion half-life is extended.


-Chronic generalized candidiasis

-Acute and recurrent candidiasis

-Prevention of vaginal candidiasis (3 times per a year or more)

-Skin mycoses (Dermatophytosis) Tinea pedis, Tinea corporis, Tinea versicolor

-Candidiasis of cavitas oris, pharynx and esophagus

-Onychomycosis, shingles (tinea)

-Prevention of candidiasis in antibiotic therapy

-Prevention of fungal infections in immune suppressed patients receiving radiotherapy and chemotherapy


Can’t be used, if there is a high sensitivity to fluconazole and to other members of this group.


Fluconazole is generally perceived quite well. However, nausea and vertigo can be observed sometimes.


For acute vaginal candidiasis, a dose of 150 mg is prescribed, 1 time per a day. For chronic vaginal candidiasis, a dose of 150 mg, 3 times per a week. For prevention of recurrences of chronic vaginal candidiasis, a dose of 150 mg, 1 time per a month, throughout 4-12 months. For shingles (tinea), a dose of 300 mg per a week, throughout 2 weeks.


In blisters with 2 capsules.