PHARMACODYNAMICS: GEROLIN stimulates the biosynthesis of structural phospholipids of neuronal membranes, improves the functioning of membrane mechanisms such as ion pumps and receptors; without regulation of which there cannot be normal conduction of nerve impulses. Due to the stabilizing effect on the neuronal membrane, GEROLIN identifies decongestants properties that help in reabsorbing of cerebral edema. GEROLIN inhibits the activation of several phospholipases, decreasing the formation of free radicals and prevents degradation of membrane systems and stores the antioxidant protective systems, such as glutathione, besides, stores neuronal energy reserve, inhibits apoptosis and stimulates the synthesis of acetylcholine. GEROLIN, also exhibits prophylactic neuroprotective effect in focal cerebral ischemia, improves the level of attention and awareness, reduces the appearance of amnesia, cognitive and neurological disorders associated with cerebral ischemia.
Bioavailability is 99 %. When administrated intravenously and intramuscularly the citicoline is being metabolized in the liver to produce choline and cytidine. After parenteral administration the choline concentration in the plasma of blood is increasing. Maximum concentration in plasma is from 1 to 24 hours (2ndpeak). Citicoline is largely distributed in the brain structures with rapid realization of the choline fractions into the structural phospholipids and cytidine fractions – in cytidine nucleotides and nucleic acids. Citicoline penetrates into the brain and is actively integrated into cellular, cytoplasmic and mitochondrial membranes, forming a structural part of the fraction phospholipids. Only 16 % of the administered citicoline dose is excreted from human body; 3 % by kidney, 1% by intestine and about 12 % with exhaled CO2.
• Acute ischemic stroke and neurological effects
• The recovery period of ischemic and hemorrhagic strokes
• Traumatic brain injury, acute and recovery period
• Surgical intervention in the brain
• Decompensation of chronic cerebrovascular insufficiency
• Cognitive disorder in vascular and degenerative diseases of the brain
Disorder of memory and other mental functions:
• «The physiological aging"
• Mental retardation
• Sleep disorders and phobias
Vertigo of various origins
• Drug intoxication
Complex treatment of other pathologies:
• Asteno – depressive syndrome
• Acute pancreatitis or acute exacerbations of chronic pancreatitis, postoperative acute pancreatitis.
CONTRAINDICATIONS:high sensitivity to the components of the medication.
GEROLIN used for intravenous or intramuscular administration which is prescribed in a slow injection form (during 3-5 min) or drip form (40-60 drops per minute). The recommended dose for is 500-2000 mg per a day. The medication is compatible with all isotonic solutions for intravenous administration, as well as with hypertonic solutions of glucose.
In the acute phase of cerebrovascular disorder, it is prescribed at a dose of 500-1000 mg 1 - 2 times per a day as intravenous administration, during the first 2 weeks, then500-1000 mg 1 - 2 times per a day as intramuscular administration. In Parkinsonism, it is prescribed at a dose of500 mg 1 time per a day, during 3-4 weeks. In hemiplegia, after acute cerebrovascular disorders it is prescribed at a dose of1.0 g 1 time per a day, during 4 weeks. In acute pancreatitis (together with inhibitors of proteolytic enzymes), it is prescribed at a dose of 1.0 g 1 time per a day, during 2 weeks.
For children: 0-1 year - 1/3 ampoules; 1-5 years - 1/2ampoules 1 time per a day.
Solution for injection, 4ml/500 mg ampoules, № 5.